Remarkable 28
Doctors have hailed “unprecedented” trial results that show a triple-action cancer jab can eradicate entire tumours in patients. In an international trial spanning 11 countries, the injection was offered to patients whose cancer had spread or come back and whose disease had failed to respond to other treatments. The jab, called amivantamab, shrank the tumours of more than a third of patients, with dramatic changes seen within weeks. In 15 of them, doctors found the drug had melted away their tumours altogether.
Cancer jab can eradicate entire tumours in patients, trial shows
Among the list of smartphone dangers is a disconnect with the meaning of life, author Arthur Brooks says. Brooks offers three steps to bring you more fulfillment.
Scrolling on your phone may be keeping you from the meaning of life
Arsenal completed 199 passes, PSG 837. Indeed, Arsenal only completed 1.3 passes per kilometre their players ran; over 150, some 6.6 more than PSG. It was the price of not having the ball. Uefa’s possession statistics gave them a 36 percent share, Opta’s a mere 24.7; the latter felt the more accurate.
How Arsenal’s endless attrition cost them the Champions League final
But in recent months, warning signs from this once-obscure corner of finance have begun to echo concerns from past crises, raising questions about whether risks simmering in the background could spill into the broader economy. Major firms like Blackstone have seen investors withdraw billions from flagship private credit funds, raising concerns about liquidity (how easily an investment can be turned into cash) and valuation in a market that has quietly swelled to more than $1.8 trillion since the 2008 financial crisis. Once marketed as a steady, predictable source of yield, private credit is now drawing comparisons — fair or not — to past moments when risks built up out of sight.
Five Things to Know About Private Credit - Knowledge at Wharton
Ukraine’s early embrace of drones, and the mass-industrialization of their accuracy and power, has begun to exact a defining toll on Russia.
Robots are redefining the war in Ukraine – and forcing Russia onto the back foot
No, the worst of it is that our dynamic economy gave postwar Germany a sense of identity. For all our flaws, we had a country that functioned better than others. Now it doesn’t anymore, and we’re mystified. Yet a better economy is possible. It might not alter the country’s political trajectory, and it certainly won’t placate an aggrieved President Trump. But it can turn the tide on stagnation and restore the fabled resilience of German businesses. Commentators tend to focus on today’s troubles. The economy’s rise and fall is a much older story, though. At its most prosperous, Germany was a high-tax, high-wage, big-bureaucracy country — something to remember for those whose recipe for renewal is simply to cut the cost of doing business. In the postwar decades of vigorous growth, the economy itself resembled the kind of product that it so excellently manufactured, an expensive and highly complicated machine whose cogs meshed.
Those cogs included an education system geared toward supplying businesses with technically proficient workers; managers trained as engineers or scientists rather than as generalists; banks and insurers with major stakes in the largest companies and focused on long-term goals over short-term profits; and stable labor relations that offered workers secure and well-paid jobs as well as a vote in key decisions. Together, these elements contributed to the technological superiority long associated with the Made-in-Germany brand.
Germany Has Lost What It Did Best
Monster cruise ships of today face being reduced to mere minnows by plans for a floating city that will carry 80,000 people around the world. A mile-long, 800ft-wide and 30-deck-high, the £12bn Freedom Ship would house a research hospital as well as enough schools, shops and restaurants to serve a population as big as Chatham in Kent. Likely to be powered by nuclear fuel, the 2.3-million-gross-ton giant will have homes for 50,000 permanent residents and space for another 10,000 cruisers and day visitors, all served by 20,000 crew.
Nearly a mile long and 80,000 on board – welcome to the first floating city
Now, the administration has announced a tariff rate cut for agricultural and construction equipment, explicitly for the purpose of cutting costs for those industries, which have been especially hard-hit by Trump's policies. In doing so, however, the White House has effectively admitted, at long last, that American consumers and businesses are the ones who pay the price for Trump's tariffs.
Trump just gave the game away on who really pays for his doomed economic policy - Alternet.org
In 1950, the typical American would have had to spend 75 percent of his or her daily pay (after taxes) to buy a bottle of vodka. Today, that number is less than 5 percent. Atrophying alcohol taxes and growing incomes have effectively brought the cost down to one-fifteenth of what it once was. The legalization of marijuana made it much easier for anyone to buy the drug. It also has made the drug cheaper. In Oregon, the average price of marijuana per gram is down more than 60 percent since legalization. Powerful synthetic drugs, such as fentanyl and meth, have taken over illegal drug markets. These drugs went from cheap to cheaper, with the price of fentanyl dropping by 50 percent over five years. They can also be much more potent than nonsynthetic drugs, meaning users have to buy less to obtain the same high.
It’s Never Been Easier in America to Get Buzzed
California’s public universities spent $16.9 million on A.I. during a financial crisis, and the result has been chaos.
California’s Public Universities Went All in on A.I. Now They’re Tearing Themselves Apart.
Global oil inventories could hit critical levels ahead of the peak summer demand period if stock draws continue at their current pace, the head of the International Energy Agency's oil industry and markets division said on Tuesday. Fuel demand typically peaks in the Northern Hemisphere summer when people drive and fly on holiday. Sign up here. "We're seeing stock draws continuing into the summer, and with the possibility or the likelihood that we reach critical levels or historical low levels just ahead of the peak summer demand," said Toril Bosoni. It could take six to eight months in the best-case scenario to reopen the Strait of Hormuz if an agreement was reached today, Bosoni said at the S&P Global Energy Middle East Petroleum and Gas Conference in London. That could make a further IEA-coordinated emergency stock release a possibility, but that is not currently being discussed as around half of the initial 400-million-barrel coordinated release from March is yet to hit the market, she added. "In any case, emergency stock releases are only a temporary stop-gap measure, they're not going to solve this problem. The scale of the supply losses are so big that the reduction would have to come from the demand side," Bosoni said. Demand destruction is where high prices force consumers to cut back on buying until supply and demand are more balanced.
IEA forecasts chance of critically low stockpiles before peak summer demand
Something weird is happening in China. Chinese demand for oil has tumbled 9% from before the Iran war, according to JPMorgan. That’s the stuff of economic nightmares. For context, global oil demand fell 2% during the 2008 Great Recession. But China isn’t close to economic collapse. Despite the largest energy supply shock the world has ever seen … despite the fact that China imports 70% of its oil … despite China’s status as Iran’s No. 1 oil customer … the oil situation in China seems, well, fine.
The Iran war has significantly reduced global demand for oil: In March, demand fell by 2.8 million barrels per day. In April it was 4.3 million barrels per day. In May, 5.6 million. We’re not quite at the pandemic’s 10 million barrel-per-day demand loss . But we’re getting closer. Much of that will come back. Not all of it.
Did the Iran war force peak oil?
Iran has gained a new source of leverage over the global economy, and it’s not about to give it up. Tehran has shown that it is able to effectively blockade the world’s most important oil chokepoint, with relatively few missiles and drones. Its influence over the Strait of Hormuz will long outlast the conflict itself, according to multiple analysts who spoke to CNN, regardless of what it eventually agrees to with the White House. The latest exchange of strikes between the United States and Iran suggests that a deal may yet be some way off. But even if it comes, experts say it’s unlikely to strip Iran of its newfound energy weapon.
‘Their new nuclear option’: Why Iran’s influence over the Strait of Hormuz is here to stay
The $20tn (£15tn) valuation of hyperscalers, chipmakers and the larger AI complex, has wildly outpaced the electrical infrastructure needed to run data centres and sustain the technology on anything like the projected scale. The physical constraint is rock hard. “Our grid in the United States hasn’t had any meaningful upgrade since the 1970s,” said Bobby Majumder from the industrial law firm FBT Gibbons. The threat to AI stock mania is not so much lack of energy – though that is serious – but rather the global bottleneck of transformers, substations, switchgear, transmission lines and all the unsexy stuff we rarely think about, leaving aside the acute shortage of skilled workers in the US able to install and run such kit.
Energy failures are destined to doom Wall Street’s AI euphoria
Local LLMs are one of those things that started off as a novelty and ended up being more useful than I expected. After running them for months now, I'm still kind of impressed that you can hand your hardware some open weights and have a real conversation with it offline. The two I keep coming back to are Gemma 4 (the E4B variant on desktop, E2B on mobile) and Qwen 3.5 9B. I've used both for a while now and there are noticeable differences between the two. So I thought I'd put them head-to-head to see which one is actually the better option for my use cases in particular.
I ran Gemma 4 and Qwen 3.5 for the same local tasks, and one pulled miles ahead
The U.S. Navy figures it’ll take six months to clear the mines Iran laid in the Strait of Hormuz back in March. A German defense consortium just unveiled a hydrogen-powered submarine drone that, by its own engineers’ math, could do the entire job in 24 hours, with one person running it from a desk.
It’s called the Greyshark, and the long-endurance Foxtrot variant just had its specs detailed by Interesting Engineering on May 13. Sea trials are set for August. The hydrogen fuel cell version is rated for 16 weeks underwater at four knots, 10,700 nautical miles without ever surfacing, with 17 sensors that shoot the seabed at 1.6 inches per pixel. Run six of them as a swarm under a single operator and you can map the entire Strait of Hormuz in less than a day.
Huawei, China’s top tech company, has published a paper that has caught most people outside China off guard. In that paper, they claim to have found a way to circumvent US chip export controls. But not in the way you think. They call it LogicFolding, and it’s a fascinating engineering achievement. And importantly, it’s something the US and allies will have to deal with eventually, which means that, for the first time, we may be running behind. No EUV, No Problem People simplify US export controls to China as basically “you can’t buy GPUs”. In reality, though, the restrictions encompass the entire semiconductor supply chain.